Sinoway Industrial Co., Ltd

Date: 9th May 2016
Imatinib Mesylate
Sinoway Industrial Co.,Ltd is a famous China imatinib mesylate manufacturer and supplier,Website:http://www.sinoway-chem.com, welcome to buy GMP and EP imatinib mesylate from us and check the price with us.Basic information ofImatinib Mesylate:NameImatinib MesylateAliasGLIVEC;GLEEVEC;IMATINIB METHANESULFONATE; CGP-57148B; 4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]-phenyl]-benzamide Mesylate;CAS NO.220127-57-1Molecular FormulaC30H35N7O4SMolecular Weight589.71QualityStandardIn-house StandardPackage SizeAluminium bag; 50g/bag; 100g/bagBrief IntroductionImatinib mesylate (also called Gleevec) is a small-molecule inhibitor of the fusion protein Bcr-Abl, the causal agent in chronic myelogenous leukemia.As an inhibitor of PDGFR, imatinib mesylate appears to have utility in the treatment of a variety of dermatological diseases. Imatinib has been reported to be an effective treatment for FIP1L1-PDGFRalpha+ mast cell disease, hypereosinophilic syndrome, and dermatofibrosarcoma protuberans.Storage conditionPreserve in tight, light-resistant containers, and store at 15? —30? .Use of Imatinib Mesylate:A tyrosine kinase inhibitor. Highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL)echinocandin antifungal, active against infections with Aspergillus and Candida, inhibits cell wall synthesisAnticancerCOA ofImatinib Mesylate:TEST ITEMSPECIFICATIONRESULTSAppearanceWhite or slightly yellow crystalline powder, homogeneous and with fine grain size. No foreign particles are observed.Slightly yellow crystalline PowderSolubilitySoluble in water and in acids solutions,slightly soluble in methanol insoluble in acetone, acetonitrile and dilute hydroxyl alkaline solutionConfirmIdentificationCompliesConfirmWater?1.0%0.8%Heavy metals?20ppm10ppmMelting range212? 220 ?214-216?Residue on ignition?0.1%0.08%Particle size90% < 100 ?m50% < 50 ?mConfirmBulk densityNLT 0.4g/ml0.6g/mlChromatographicpurityIndividual impurities: ?0.2%Total impurities: ?0.5%0.16%0.32%Assay98.5%-102.0% of Imatinib mesylate,calculated on anhydrous basis.99.70%Residual solventsEthyl acetate: ?5000ppmConfirmAcetone: ?5000ppmConfirmN,N-Dimethylformamide: ?880ppmConfirmMethanol: ?3000ppmConfirmDichloromethane: ?300ppmConfirm
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